Water supplement had been removed two hours before oral pretreatment started. Antiulcer activities of liquorice and its derivatives in experimental gastric lesion induced by ibuprofen in rats. In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc. Intramuscular administration of morphine reduces mustard. Twentyeightday repeated inhalation toxicity study of nano. In these methods thermal and clampingcortisone ulcers seem to be valuable tools in investigation of the healing process of gastric ulcer, because of the relatively long period of its persistence and closer histologic resemblance to human peptic ulcer. Ulcer index was assessed in 100150 gm fasted albino rats after administration of ethanol.
A portion of the keratinized squamous epithelium of the tongue has been lost, exposing the underlying lamina propria. The most common symptom of a peptic ulcer is abdominal pain. Amelioration of severe tnbs induced colitis by novel ap1 and. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. Acute lung injury, antihistamine, ards, methylprednisolone, pulmonary edema acute respiratory distress syndrome ards is a common devastating clinical syndrome of acute lung injury with high mortality rate, 26 to 58%1,2. The results have provided scientific basis to the use of this plant in folk medicine as a gastric sedative.
Effect of capsaicin, resiniferatoxin and piperine on ethanolinduced gastric ulcer of the rat. Evaluation of antiulcer activity of methanolic extract of. Therapeutic value of camel milk as antiulcerogenic effect. All the treatment doses of the extracts aepo and mepo and ranitidine suppressed the ulceration induced by ethanol. Peptic ulcer, medicines, prostaglandins, gastrointestinal protection, gastrointestinal toxicity for more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. The fruit pulp was extracted with ethanol and the antiulcer activity of the extract in indomethacininduced gastric ulceration in swiss albino rats was. Orally, after 45 min of methanolic extract and omeprazole treatment. The ameliorative effect of dates phoenix dactylifera l. Gelatine tannate has been recently licensed as a medical device for the treatment of acute diarrhoea. The effects of aqueous leaf extracts of sm and fe on the ulcer index and % inhibition against ulcer in the experimental animals are shown in fig. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of non steroidal antiinflammatory drugs. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Tongue ulcer in a female f344n rat from a chronic study higher magnification of figure 1.
Biochanin a gastroprotective effects in ethanolinduced. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Druginduced peptic ulcer disease clinical pharmacist, st lukes hospital, guardamangia, malta email. The acetone extract of cucumis sativus seed reduces the paw edema induced by carrageenan by 43. B inhibitors, namely, dtcmg and dhmeq, were investigated in male wistar rats with severe colitis, induced by tnbs. In fact, no acid, no ulcer is the dictum for duodenal ulcer. Because 30% of patients having duodenal ulcer and very few patients with gastric ulcer are. Protective role of phoenix dactylifera fruit against ethanol. Previous studies done in rats showed unexpected thrombotic potencies of this drug used at ultralow doses. It is expected that this study will not only confirm the results of the 258 study but show that the incidence of ugi ulcers on celecoxib is significantly less than on traditional nsaids and the incidence of ugi ulcers on celecoxib increases with the addition of. Pdf gastroprotective effect of zingerone on ethanol. Tongue ulcer in a female f344n rat from a chronic study.
Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. Gastric mucosal lesions were produced by orally administering 200 mgkg aspirin suspended in 1% carboxymethylcellulose solution to pyloricligated male wistar rats. Effect of capsaicin, resiniferatoxin and piperine on ethanol. Antiulcerogenic effect of camel milk against ethanol. The aim of the current study is to replicate the coxa0508258 study in a multicenter, us setting, using a lower dose of asa. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks.
Normal saline and ranitidine were used as negative and positive control. Carrageenaninduced paw edema in rats the rats were divided into 4 groups n 3. Thus, in the present study we used antineutrophil serum to assess the role of neutrophils in ethanol induced injury to the gastric mucosa. This study is aimed to evaluate the effect of zingerone on ethanol induced gastric ulcers in rats. Balakrishnan 1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Each group consisted of 16 control, low, and high dose groups or 15 middle dose group rats, and eight rats per group were sacrificed after a 28day exposure period. Gastroprotective effect of zingerone on ethanol induced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553. Gelatine tannate is thought to act locally on the gut wall by forming a protective proteinbased film and allowing the precipitation of proinflammatory mucoproteins from the intestinal mucus responsible for local inflammation, and subsequently eliminated. Antiulcerogenic effect of cuphea ignea extract against ethanol. The journal of biological chemistry 2003 by the american. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Gastric ulcers were induced in sprague dawley rats using one oral dose. Pdf gastroprotective effects of betanin against ethanol.
Nicorandil 3 and 10 mgkg given orally to rats dosedependently inhibited the development of acidrelated damage. Mar 30, 2015 diosmin lowers ulcer index a and area of gastric lesions b in rats with ethanol induced gastric injury. The results obtained indicate that the acetone extract has significant antiinflammatory activity in rats. Clonidine pretreatment inhibits stressinduced gastric ulcer. Effect of ethanolic extract of coconut cocos nucifera on aspirin. Gastric ir injury was induced according to wada et al. We investigated the mechanism underlying the protective effects of ginger against gastric damage induced by aspirin in rats. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight. Beneficial effects of nacetylcysteine on acetic acid. Thus, in an experimental model of gastritis induced by iodoacetamide, souza et al observed that, after the administration of aspirin 50 or 100 mgkg, the levels of lxa 4 in gastric mucosa of rats with gastritis were significantly higher than in healthy rats. The effect of oral administration of raw camel milk 5 mlkg b. The effect of nicotine on ethanolinduced gastric ulcers in rats.
A novel antioxidant and antiapoptotic role of omeprazole to. Effects of nicorandil on experimentally induced gastric. Perhaps at the highest dose consumed in this study 4. Rats were administered intrarectal saline control group or acetic acid colitis model group. Protection of ethanol induced ulcers by sodium cromoglycate. In ethanol induced models of the stomach mucosa ulcerations we observed abundant mucosal lesions, accompanied by the acute rise of no fig. Acetyl salicylic acid asa is widely used in clinical practice.
Diosmin lowers ulcer index a and area of gastric lesions b in rats with ethanolinduced gastric injury. Similarly, rats prefed with morus alba extract for 4 days displayed significant low ulcer index, with a protective efficacy comparable to lansoprazole, in an ethanol induced ulcer model ahmad et. Evaluation of the antiulcer effect of aerva javanica aerial. In conclusion a significant protective effect of camel milk against ethanol and aspirin induced gastric ulcers was reported in rats. Braden scale for predicting pressure ulcer risk is a widely used standardized risk assessment tool. Although gastric ulcer patients show normal or reduced level of acid secretion, duodenal ulcer patients usually secrete more acid 9, 10. Nabumetone and dipyrone are non acidic, nonsteroidal antiinflammatory drugs. Pheniramine maleate attenuates oleic acidinduced acute. Low ethanolconsuming and medium ethanolconsuming rats developed a similar incidence of these lesions, while high ethanolconsuming rats showed the lowest incidence of intestinal ulcer. The proposed cheek mucosa ulcer model in rats can be considered an efficient process that offers reliable, reproducibility, and a low cost. The rats were fasted for 24 hours before the oral gavage pretreatment food but not water.
Antiulcerogenic effect of camel milk against ethanol induced. Treatment nearly all peptic ulcers will be treated with a proton pump inhibitor ppi like omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole, dexlansoprazole and h2 blockers like ranitidine, cimetidine, famotidine and nizatidine. Effect of sesame oil on acidified ethanolinduced gastric mucosal injury in rats article in journal of parenteral and enteral nutrition 334. Diosmin attenuates gastric histopathologic aberrations and influx of leukocytes the current study next explored whether dio can protect against the histopathologic damage associated with ethanol induced gastric injury in rats. Protective effect of chelerythrine against ethanolinduced. Research article ethanolinduced gastric ulcer in male wistar. Ligatureinduced alveolar bone loss and the inflammatory parameters is reduced in rats treated with naproxen or its h 2 sreleasing derivative atb346. Intramuscular administration of morphine reduces mustard oilinduced craniofacial muscle pain behavior in lightly anesthetized rats seung r. Fourday treatment with che in ulcer induced groups have notably enhanced the mucus secretion fig.
Gastroprotective effect of zingerone on ethanolinduced gastric. T1 clonidine pretreatment inhibits stress induced gastric ulcer in rats. The different groups were treated with acetone extract of cucumis sativa 200 and 400 mgkg, p. The permanence time of the ulcer allows for testing of alternative therapies in vivo that have so far only been used empirically. Gastric side effects represent the most common adverse drug effects of the widely used nonsteroidal antiinflammatory drugs. The aqueous extract of chamomile and liqurice and chamomile oil exhibited significant p ulcer activity in this ulcer induced models compared with omeprazole as standard drug. Protective role of phoenix dactylifera fruit against ethanol induced gastric ulcer in wistar rats background. Fruit pulp extract on indomethacininduced gastric ulcer in albino. Research article ethanolinduced gastric ulcer in male. Amelioration of severe tnbs induced colitis by novel ap1. Gastric ulcers were induced in wistar albino rats by oral administration of indomethacin 200 mgkg, alcohol 80%, 1 ml100 gm and by pyloric ligation. Effect of sesame oil on acidified ethanolinduced gastric. The anti ulcer effects of nicorandil n2hydroxyethylnicotinamide nitrate ester were examined on waterimmersion plus restraint stress induced and aspirin induced gastric ulcers in rats, compared with those of cimetidine. Evaluation of antiulcer effect of amlodipine in gastric.
Antiulcerogenic activity of scutia buxifolia on gastric. Experimental model of traumatic ulcer in the cheek mucosa of rats. Protective effects of ginger against aspirininduced gastric. Evaluation of cytoprotective properties of sodium cromoglycate on ethanol induced ulcer was performed in albino rats. Both of them are known to have weak inhibitory effects of cyclooxygenases. The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats.
It is expected that this study will not only confirm the results of the 258 study but show that the incidence of ugi ulcers on celecoxib is significantly less than on traditional nsaids and the incidence of ugi ulcers on celecoxib increases with the addition of asa, but. The aim of this study therefore is to evaluate the protective effects of nebivolol against cold restraint stress crs induced gastric ulcer in rats. The gastric ulcers were induced in rats by administrating absolute ethanol 90% 1ml200g. Twentyeightday repeated inhalation toxicity study of. Rats with acetic acid induced colitis were treated by intraperitoneal or intrarectal administration of nacetylcysteine 500 mg kg treated group. Effects of nabumetone and dipyrone on experimentally induced. A preliminary study of the antiinflammatory and anti. Gelatine tannate for the treatment of acute diarrhoea in. Effect of ethanolic extract of coconut cocos nucifera on aspirininduced gastric ulcer in albino rats. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Hyp1, a novel diamide compound, relieves inflammatory and. Finally, the same positive effect of the oral administration of camel milk was observed in rats with naproxen induced peptic ulcers. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n.
Gastroprotective effect of zingerone on ethanolinduced. Research paper ulcer prevention effect of 3,4,5tihydroxyn0. Intramuscular administration of morphine reduces mustard oil. These results suggested a possible benefit of milk supplementation in treating peptic ulcer. Diosmin attenuates gastric histopathologic aberrations and influx of leukocytes the current study next explored whether dio can protect against the histopathologic damage associated with ethanolinduced gastric injury in rats. Diosmin protects against ethanolinduced gastric injury in. Distance from the cementoenamel junction cej to the alveolar bone crest analyzed by digital xray images n 8. Effect of liqurice and chamomile extracts in the management. The gastric effects of these drugs may be comparable in experimental ulcer models.
Portulaca oleracea, gastric ulceration, ranitidine, ulcer index, rats. Effect of aspirin treatment on the prevention of esophageal. The effect of nicotine on ethanolinduced gastric ulcers. To study anti ulcer effect of amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation induced gastric ulcers in wistar rats. Intramuscular administration of morphine reduces mustard oil induced craniofacial muscle pain behavior in lightly anesthetized rats seung r.
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